Z-VAD-FMK

A pan-caspase inhibitor

Product Overview

Product Name: Z-VAD-FMK

Alternate Name/Synonyms: Z-VAD-FMK, Z-VAD-fluoromethylketone, Caspase-Family Inhibitor (fluoromethylketone)

Description: A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Peptide Sequence: Z-Val-Ala-Asp(OMe)-FMK

Appearance: Lyophilized solid

Formulation: N/A

CAS Number: 187389-52-2

Molecular Formula: C₂₂H₃₀N₃O₇F

Molecular Weight: 467.5

Purity: Single spot by TLC

Solubility:DMSO (20 mM)

Storage Temp.: -20°C

Shipping Conditions: gel pack

Handling: Protect from light and moisture

SMILES: CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1

InChi: InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)

InChi Key: MIFGOLAMNLSLGH-UHFFFAOYSA-N

PubChem CID: 5737  

MDL Number: MFCD01074990

USAGE: For Research Use Only! Not For Use in Humans.