Constraints by cyclization at either the backbone or side chain of the peptide are expected to reinforce and enhance the stability of the 3D-structure, such as α-helix, as well as the increment of the resistance to the enzymatic digestion.

Cyclized Peptides

cyclo(X1-X2——–Xn)
Head-to-tail cyclization

X = NH : polypeptide
X = O : depsipeptide
(including N-methyl amino acids)

Diketopiperazine
 

R=H : cyclo(X-Pro)
R=OH : cyclo(X-Hyp)

cyclo(X-X)

Staple peptide

site-specific ligation using olefin metathesis

Cyclization at side chain

Lactone/Thiolactone

X=O : lactone
X=S : thiolactone

Thioether

Deamino-dicarba

[Asu 1,6]-Oxytocin
(Deamino-Dicarba-Oxytocin)

Oxytocin

Branched Peptides（Isopeptides）

Branched at Asp/Glu

n=1 : Asp
n=2 : Glu

Branched at Lys

Branched at Ser/Thr

X=H : Ser
X=CH3 : Thr

We have lots of successful syntheses of the cyclic peptides as well as the branched peptides.

Please contact us for additional information or send an email to peptide@synpeptide.com

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