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Stable Isotope Peptides for Quantitative Proteomics - Heavy Peptides


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To date, quantitative protein analysis has mostly relied on antibody-based (e.g. ELISA) methods. Recent advances in the sensitivity and reliability ofLC-MS instrumentation are making mass spectrometry-based methods competitive for doing quantitative protein analysis. Additionally, LC-MS methods can be multiplexed so that hundreds to thousands of proteins can be quantified in a single assay, which is a huge advance for both discovery of biomarkers as well as clinical diagnostic assays. The gold standard for MS-based quantitative methods is to use a mass-shifted, stable-isotope-labeled peptide standard spiked into the sample of interest, which then allows quantification from a simple ratio of the labeled peak height to the unlabeled. This stable isotope dilution (SID) method is the basis for all selective reaction monitoring (SRM) and multiple reaction monitoring (MRM) method.

Synpeptide is please to offer isotope labeled peptides , the industry's first complete suite of peptide and antibody SIS products and services. A world leader in isotope labeled peptides since 1998, Synpeptide has the experience, knowledge, products and services to be your one-stop shop all peptide based  quantitative proteomics needs.

Stable Isotope Labeled Amino Acids and Resins

· Isotopically labeled resins - Arg (+10) and Lys (+8) loaded resins for peptide synthesis

· Isotopically labeled amino acids  for peptide synthesis 

· SISCAPA Assay Technologies tryptic Statle Isotope Standard for SISCAPA workflows.

Custom Heavy Peptide Synthesis

· All isotope labeled peptides are optimized for the best mass spectrometry performance

· All standard heavy peptides with >99% Isotopic Purity

· Individual peptides with purities including crude, >75%, >85%, >90%, >95% and >98%

· In-house Amino Acid Analysis for accurate quantitation

· 1nmol, 10nmol, 1mg, 5mg, to gram quantities

· Customized aliquotting and kitting - choose your size and quantity!

· 96 peptide array format available

· Please do not hesitate to contact us for your request.


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